Resveratrol is a polyphenolic compounds , mainly from grapes ( red wine ) , knotweed , peanuts, mulberry and other plants . Resveratrol is a EHPural biological strong polyphenols , also known as Qi three phenol, is cancer chemopreventive agent , but also to reduce platelet aggregation, prevention and treatment of atherosclerosis , cardiovascular and cerebrovascular diseases chemopreventive agent. USDA 's findings show that the peanut kernel also contains red and quite a lot of resveratrol. Experimental studies have shown that resveratrol has on cardiovascular disease and cancer beneficial effect. Resveratrol on hormone-dependent tumors have significant preventive effect. Also on osteoporosis, acne and dementia have a preventive effect , with anti- virus and immune regulation. One monomer on the body's internal anti-aging enzymes play a role, and then play the prevention of various age-related diseases, the potential role of life expectancy .
Resveratrol is a EHPural antioxidant , can reduce blood viscosity , inhibiting platelet aggregation and vasodilation to maintain blood flow , can prevent the occurrence and development of cancer , has anti- atherosclerosis and coronary heart disease , ischemic heart disease, high blood cholesterol in rats . Role in tumor suppression also has estrogen-like effects that can be used to treat breast cancer and other diseases.
Antipyretic and analgesic effect
Resveratrol through a variety of different ways to play a therapeutic effect, with certain antipyretic and analgesic activity. Mice and rats in the full body of research shows that resveratrol does not affect blood pressure in the case confer resistance due to gastric secretion of gastric mucosa caused by the suppression of stress ulcer capabilities.
Anti-cancer , anti- mutagenic effect
1993 , Jayafilake other studies show that trans -resveratrol and cis -resveratrol has anti-cancer activity , the reason is that they can inhibit protein - tyrosine kinase activity . Jang et research team further noted that resveratrol in cancer occurs three phases namely initiation, promotion and development process, has a greater anti-cancer activity, and on the three stages of cancer inhibition and even reversal effect : First , the initial inhibition effect. Reduce the formation of free radicals , pharmacokinetic enzyme induction phase Ⅱ increased dioxin antagonistic role ; Second, to enhance the role of inhibition . Inhibition of cyclooxygenase (COX), inhibition of catalase ; three inhibiting development role . Inhibit cancer cell proliferation and induce cell differentiation , induction of apoptosis in cancer cells . Resveratrol is expected to PTK as protein tyrosine kinase inhibitors , many medical study found that resveratrol on breast cancer, stomach cancer, colon cancer, prostate cancer, leukemia , ovarian cancer, skin cancer and other malignant cell significantly inhibited .
In the private sector, has long been used in traditional Chinese medicine Polygonum cuspidatum resveratrol -rich treatment and prevention of high cholesterol, arteriosclerosis. Studies have shown that resveratrol mainly from the following aspects play an anti- atherosclerosis , coronary heart disease prevention and thus play a protective effect on the cardiovascular : 1, regulating blood lipids ; 2 , inhibition of platelet aggregation , and promote fibrinolysis, anti-thrombotic forming effect; 3, the protection of vascular endothelium, inhibition of endothelial cell proliferation ; 4, protection of vascular smooth muscle cells, inhibit the proliferation ; 5 , anti-leukocyte function ; 6 , antagonizing endothelin -1 (endothelin-1, ET-1) effect; 7 , anti- LDL -oxidation function . Some studies , including toxins or thrombin -induced platelet activation in rats found washed platelets with resveratrol pre- incubation, at physiological concentrations in plasma LPS alone or LPS and thrombin activated platelets on collagen adhesion is blocked . Platelet adhesion pretreated with resveratrol fibrinogen have also been blocked . Resveratrol and its derivatives are more recent study of a class of phytoalexin , its cardiovascular protective effects gradually become a hot topic , is expected in the prevention and treatment of cardiovascular diseases, drug development make a difference, but its mechanism of action is far from clear , pending further study.
Prevention of heart and liver damage
Resveratrol inhibits mouse liver triglycerides and cholesterol deposition . It also can inhibit the liver lipid peroxidation which prompted aspartate aminotransferase and alanine aminotransferase levels rise. By analyzing these two enzymes in serum , liver, heart, and can be obtained in good diagnostic information.
Resveratrol inhibits lipoxygenase synthesis , the enzyme present in leukocytes, heart, brain , lung and spleen . Therefore, resveratrol prevents the formation of blood clots in blood vessels . And the use of antihypertensive drugs such as clonidine treatment, it also inhibits platelet build-up.
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