Product name: Berberine hydrochloride
Synonym: Berberine sulphate
5,6-dihydro-9,10-dimethoxy benzo [g]-1,3-benzodioxolo
[5,6-α] quinolizinium hydrochlorate dihydrate.
M.F. &M. W. : C20H18NO4+; 336.37
CAS NO.: 480-41-1
Physical Property: hydroxyl compound is yellow needle crystalline (aether); M.P.: 145℃; dehydration of chloride is yellow crystalline; slightly soluble in cold water, freely soluble in hot water, practically insoluble in ethanol, chloroform; iodide M.P.: 263-265℃(disassembled).
1.Anti-microbial & anti-protozoon, in vitro tests show: A.anti-bacterial actions: berberine has strong bacteriostatic action on hemolytic streptococcus, meningococcus, vibrio cholerae, bacillus anthraci, bacillus subtils and ataphylococcus aureus; and the same function to shigella dysenteriae, corynebacterium diphtheriae, viridans streptococci, pneumobacillus etc. It has small effect on proteusbacillus vulgaris escherichia coil and typhoid bacillus, and practically inaction on songs shigella dysenteriae, paratyphoid bacillus and pseudomonas aeruginosa. B.Anti-other-microorganism and protozoon: killing effect on leptospira at 7.5ug/ml, anti-amoeba effect with sulfate in vitro or in vivo, efficiency in vitro equals to 1/128 of emetine and 1/4 of tetrandrine; efficiency in vivo equals to 1/16 of tetrandrine.
2.Actions on circulatory system: intravenous injection or oral administration, causing dropping of blood pressure to narcotic dogs, cats and rabbits or non-narcotic rats.
3.Actions on neurotransmitter: on the sample of mammals` hearts, declares that berberine can enhance the effect of acetyl choline at small dosage, but counteraction at large dosage. Similarly to overall animals, and some anti-epinephrine functions.
4.Actions on smooth muscle: except loosing function on vessel smooth, it has effect on other smooth muscles such as womb, bladder, bronchus, intestines and stomach.
5.Influence on choleresis and haemal: cholagogue, increasing bile formation, and diluting bile. Better effect to chronic cholecystitis by oral administration. In chronic tests, it can decrease aerum cholesterol by oral administration 20mg/kg and intramuscular injection 2mg/kg to rat.
6.Other functions: excitement in cerebral cortex on rat at small dosage, but reducing at large dosage. Antipyretic, anti-diuresis, local anaesthesia, mitigation, analgesia, and prolong sleeping time of pentobarbital, reducing intra-ocular pressure of rabbits.
7.Clinical applications and toxic side effects: mainly for the treatment of bacillary dysentery, typhoid fever, phthisis, epidemic cerebrospinal meningitis, lung abscess, hypertension, brucellosis, acute tonsillitis, maxillary sinusitis, oromaxillo-facial region infection etc.. The curative dosage is safe, with few side effects, without any toxic and side effect with long term administration.
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